DURHAM, N.C. (AP) - Quentin Harris passed for 202 yards and three touchdowns before leaving with an injury as Duke beat North Carolina Central 55-13 on Saturday.
Brittain Brown rushed for 118 yards and a score and added a 43-yard touchdown catch to help the Blue Devils start 4-0 in back-to-back seasons for the first time since 1952-53.
Duke scored touchdowns on its first three possessions and piled up 628 total yards, improving to 7-0 against its city rival from the Football Championship Subdivision.
Harris, who also ran for a score in his second career start in place of injured Daniel Jones, hurt his left leg with Duke leading 34-13 early in the third quarter. N.C. Central's Randy Anyanwu rolled into Harris' front leg as Harris delivered a pass, and Harris limped off the field after receiving medical attention. Harris rode an exercise bike and stood with his teammates on the sideline but did not return to the game.
Brown had departed two plays earlier with an injured left arm and did not return.
Isaiah Totten rushed for 88 yards and a touchdown, all in the first half, for N.C. Central (1-2). Totten, who had a 59-yard run in the first quarter, missed the second half with an injured left shoulder.
N.C. Central: The Eagles were full of fight, if not flight, for a half. They trailed just 20-13 late in the second quarter after falling behind 20-0 in the game's first nine minutes.
Duke: The Blue Devils got off to a fast start before getting sloppy in the second quarter. Part of the problem was uneven play from Harris, who misfired on several passes to open receivers. Jones is trying to return ahead of schedule from his broken clavicle, but Harris and third-stringer Chris Katrenick will be challenged in the meantime as Duke's schedule gets more difficult.
N.C. Central: The Eagles host Florida A&M in their Mid-Eastern Athletic Conference opener.
Duke: The Blue Devils host Virginia Tech in their Atlantic Coast Conference opener.