Tyler Wilkerson scored a career-high 25 points to lead Marshall to an 83-49 win over East Carolina on Saturday.
Markel Humphrey added 15 points for Marshall (12-10, 4-5 Conference USA). Tirrell Baines scored 14 and Mark Dorris added 10 points.
Wilkerson had 19 first-half points on 9-of-10 shooting to give Marshall a 36-25 lead at halftime, and the Pirates got no closer in the second half.
Marshall's lead grew to as many as 36 points on the strength of 54 percent shooting in the second half.
No players for East Carolina (8-13, 2-6) scored in double figures. Leading scorer Sam Hinnant, who had 24 points in the first meeting this season between the teams, was held to six points.
The Pirates were outrebounded 42-24.