The Detroit Pistons jumped out to a double-digit lead in the first seven minutes then cruised to a 104-85 victory over the Bobcats.
"It's hard," said Antonio McDyess, who had 19 points and nine rebounds. "You get out to a big lead against a team like that, and you start to lose your focus."
After Detroit took an early 22-10 lead, the Bobcats only closed within single digits for a short spell early in the third quarter.
"We ran out of gas in the first five minutes of the game," Charlotte coach Jay Vincent said. "Right now, it is tough for us in back-to-back situations, because we just don't have the depth. We played a tough game last night and then had to get on a plane and come here."
Charlotte had snapped a seven-game skid by beating Cleveland Saturday, while Detroit got a day off at home after losing to Chicago on Friday.