DURHAM, N.C. (AP) -- Sean Renfree threw for 314 yards and four touchdowns to lead Duke past Memphis 38-14 on Saturday night.
Renfree was 26 of 37 with TDs covering 37 and 31 yards to Conner Vernon, 16 yards to Desmond Scott and 8 yards to Brandon Connette for the Blue Devils (3-1), who outgained the Tigers 500-152 and are off to their best start since 2008.
Connette also had a 4-yard touchdown run for Duke, which had four turnovers -- two in the red zone, a third returned for a touchdown -- but held Memphis (0-4) to less than 100 total yards until late in the third quarter.
Wynton McManus took an interception 4 yards for a score and Tevin Jones added a 2-yard touchdown run for the Tigers, who led 14-7 in the second quarter but couldn't hold on. The Tigers have lost 35 of 40 games since 2009.