The Humane Society of Missouri says it rescued more than 150 dogs and a Bengal tiger from a substandard dog breeder near Seneca.
The group says the rescue Thursday with the Newton County Sheriff's department was its second major puppy mill raid in less than a week.
It says the dogs' cages were covered with waste and they had no food or water.
About 30 puppies and four pregnant canines were among the dogs taken to St. Louis for treatment pending a custody hearing March 9.
The adult tiger was taken to a Springfield zoo. The same breeder in Newton County was raided two years ago. The state seized 150 dogs but didn't file charges.
The Humane Society also raided a breeder in Greene County on Feb. 13 and rescued 100 Yorkies.