Emergency crews were on the scene of an accident that caused traffic back-ups at the intersection of Firetower and Evans in Greenville.
Police say a van was making a left from Evans to Firetower and a truck was traveling South on Evans when the accident happened.
The driver and a passenger in the truck were transported to the hospital with what police believed were non life-threatening injuries.
Police had lanes closed for several hours.
Charges are pending as the investigation continues.